In Vitro–to–In Vivo Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach
Aditya R. Kumar, Bhagwat Prasad, Deepak Bhatt, Sumathy Mathialagan, Manthena V. S. Varma, Jashvant D. Unadkat
Topics & Concepts
In vivoTransporterClearancePharmacokineticsPharmacologyIn vitroChemistryOrganic anion transporter 1Distribution (mathematics)BiologyBiochemistryMedicineGeneUrologyMathematical analysisMathematicsBiotechnologyDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesPharmacogenetics and Drug Metabolism