<i>Bifidobacterium longum</i> S3 alleviates loperamide-induced constipation by modulating intestinal acetic acid and stearic acid levels in mice
Tong Zhang, Huimin Lu, Ting Cheng, Linlin Wang, Gang Wang, Hao Zhang, Wei Chen
Abstract
group. These changes may thereby increase acetic acid and stearic acid (C18:0) levels, which significantly increase the expression levels of ZO-1 and MUC-2, repair intestinal barrier damage and reduce inflammation (IL-6). Furthermore, it also inhibited oxidative stress levels (SOD and CAT), decreased the expression of water channel proteins (AQP4 and AQP8), significantly elevated the Gas, 5-HT, PGE2, and Ach levels, and reduced nNOS and VIP levels to improve the intestinal luminal transit time and fecal water content. Collectively, these changes resulted in the alleviation of constipation.
Topics & Concepts
LoperamideBifidobacterium longumStearic acidConstipationAcetic acidPharmacologyMedicineChemistryBifidobacteriumDiarrheaInternal medicineLactobacillusFood scienceBiochemistryFermentationOrganic chemistryGastrointestinal motility and disordersDiet and metabolism studiesInfant Health and Development