Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer
Yao Xiao, Wenxia Yao, Mingzhen Lin, Wei Huang, Ben Li, Bin Peng, Qinhai Ma, Xinke Zhou, Min Liang
Abstract
Our findings validate that the successful design of PLGA@Icaritin, which can effectively active ICD and facilitate tumor recruitment in GC through inducing mitoDNA oxidative damage.
Topics & Concepts
PLGAFlow cytometryIn vivoCancer cellApoptosisChemistryReactive oxygen speciesImmune systemCellCell biologyBiophysicsIn vitroCancerBiologyBiochemistryMolecular biologyImmunologyBiotechnologyGeneticsMedicinal Plant Pharmacodynamics ResearchCancer-related molecular mechanisms researchImmunotherapy and Immune Responses