COVID-19 - Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines
Mohd. Iqbal Yatoo, Zeenat Hamid, Oveas Rafiq Parray, A. H. Wani, Abrar Ul Haq, Archana Saxena, Shailesh Kumar Patel, Mamta Pathak, Ruchi Tiwari, Yashpal Singh Malik, Ranjit Sah, Ali A. Rabaan, Alfonso J. Rodríguez‐Morales, Kuldeep Dhama
Abstract
The COVID-19 pandemic caused by SARS-CoV-2 has spread rapidly. To date, countries have relied on the prevention of the disease through isolation, quarantine, and clinical care of affected individuals. However, studies on the roles of asymptomatic and mildly infected subjects in disease transmission, use of antiviral drugs, and vaccination of the general population will be very important for mitigating the effects of the eventual return of this pandemic. Initial investigations are ongoing to evaluate antigenic structures of SARS-CoV-2 and the immunogenicity of vaccine candidates. There also is a need to comprehensively compile the details of previous studies on SARS-related vaccines that can be extrapolated to identify potent vaccine targets for developing COVID-19 vaccines. This review aims to analyze previous studies, current status, and future possibilities for producing SARS-CoV-2 vaccines.