DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis
Farhana Rahman, Jennifer L. Johnson, Jinzhong Zhang, Jing He, Kersi Pestonjamasp, Stéphanie Cherqui, Sergio Catz
Abstract
: ACTB: actin, beta; ATF4: activating transcription factor 4; CMA: chaperone-mediated autophagy; DYNC1LI1: dynein cytoplasmic 1 light intermediate chain 1; DYNC1LI2: dynein cytoplasmic 1 light intermediate chain 2; ER: endoplasmic reticulum; LAMP1: lysosomal associated membrane protein 1; LAMP2A: lysosomal associated membrane protein 2A; LIC: light-intermediate chains; LRP2/Megalin: LDL receptor related protein 2; PTCs: proximal tubule cells; RAB: RAB, member RAS oncogene family; RAB11FIP3: RAB11 family interacting protein 3; RILP: Rab interacting lysosomal protein.
Topics & Concepts
AutophagyBiologyCystinosisCell biologyHomeostasisTFEBReceptorIron homeostasisGeneticsGeneBiochemistryApoptosisCysteineCystineEnzymeBiomedical Research and PathophysiologyNeonatal Health and BiochemistryAmino Acid Enzymes and Metabolism