Designing spike protein (S-Protein) based multi-epitope peptide vaccine against SARS COVID-19 by immunoinformatics
Hitesh Singh, Renu Jakhar, Neelam Sehrawat
Abstract
cloning was used to analyse its expression in vector. Molecular docking was performed to study the interaction of construct with TLR (TLR3, TLR4, and TLR9) molecules. The immune simulation was conducted and conformed that our vaccine constructs can induces both acquired and humoral immunity effectively against COVID-19 at very low concentration, but along with bioinformatics study we need to conduct experiment in laboratory to validate its safety and effectiveness.
Topics & Concepts
ImmunogenicityEpitopeAdjuvantPeptide vaccineVirologyIn silicoBiologyComputational biologyAntigenImmunologyGeneGeneticsvaccines and immunoinformatics approachesMonoclonal and Polyclonal Antibodies ResearchSARS-CoV-2 and COVID-19 Research