Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity
Carolyn Rydyznski Moderbacher, Sydney I. Ramirez, Jennifer M. Dan, Alba Grifoni, Kathryn M. Hastie, Daniela Weiskopf, Simon Bélanger, Robert Abbott, Christina Kim, Jinyong Choi, Yu Kato, Eleanor G. Crotty, Cheryl Kim, Stephen A. Rawlings, José Mateus, Longping V. Tse, April Frazier, Ralph S. Baric, Bjoern Peters, Jason Greenbaum, Erica Ollmann Saphire, Davey M. Smith, Alessandro Sette, Shane Crotty
Abstract
T cell, and antibody responses are protective, but uncoordinated responses frequently fail to control disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2.
Topics & Concepts
BiologyImmunityCoronavirus disease 2019 (COVID-19)ImmunologyAcquired immune systemSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Immune systemDisease2019-20 coronavirus outbreakAntigenVirologyBetacoronavirusInfectious disease (medical specialty)Internal medicineMedicineOutbreakSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19