Hyaluronan and elastin-like protein (HELP) gels significantly improve microsphere retention in the myocardium
Riley A. Suhar, Vanessa M. Doulames, Yueming Liu, Meghan E. Hefferon, Oscar Figueroa, Hana Buabbas, Sarah C. Heilshorn
Abstract
retention of microsphere cargo compared to Matrigel, both 1 day and 7 days post-injection directly into the rat myocardium. These data suggest that HELP gels may assist with the clinical translation of therapeutic cargo designed for delivery into the contracting myocardium by preventing acute cargo loss.
Topics & Concepts
ElastinMicrosphereRetention timeChemistryBiomedical engineeringMedicinePathologyChromatographyChemical engineeringEngineeringTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical ApplicationsCardiac Valve Diseases and Treatments