Controlling selectivity in N-heterocycle directed borylation of indoles
Safia Iqbal, Kang Yuan, Jessica Cid, Jürgen Pahl, Michael J. Ingleson
Abstract
N-Heterocycle directing groups lead to selective borylation of indole at C2 or C7 controlled by heterocycle ring size. With five membered heterocycle directing groups, C2 borylation is disfavoured due to an increased degree of distortion.
Topics & Concepts
BorylationSelectivityChemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalysisArylAlkylOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods