Endoplasmic reticulum-targeting activatable nanophotosensitizers for hypoxia relief and enhanced photodynamic therapy
Shanchao Diao, Xiaowen He, Ying Wu, Likun Yin, Yuxin Huang, Wen Zhou, Chen Xie, Quli Fan
Abstract
studies demonstrate that TPPa-Y NPs have a better anticancer effect than the nanoparticles without YC-1 (TPPa NPs). Therefore, this study provides a smart nanophotosensitizer, which is able to target ER and alleviate hypoxia for PDT efficacy enhancement.
Topics & Concepts
Endoplasmic reticulumPhotodynamic therapyHypoxia (environmental)Cell biologyChemistryBiophysicsCancer researchMedicineBiochemistryBiologyOxygenOrganic chemistryNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryCancer, Hypoxia, and Metabolism