Gut microbiota and dynamics of ammonia metabolism in liver disease
Deepika Jakhar, Shiv Kumar Sarin, Savneet Kaur
Abstract
Blood ammonia levels in healthy individuals are low, but they increase in liver disease due to loss of functional liver mass and portosystemic shunting. Hyperammonemia is one of the key factors involved in the prognosis of cirrhosis and its complications. Here we review to establish a connection between alterations in gut microbial communities and intestinal ammonia metabolism, highlighting a key impact of gut dysbiosis on blood ammonia levels during liver disease.
Topics & Concepts
MetabolismDynamics (music)Gut floraLiver diseaseBiologyMicrobiologyBiochemistryPsychologyPedagogyDiet and metabolism studiesLiver Disease Diagnosis and TreatmentClinical Nutrition and Gastroenterology