Regulation of apical constriction via microtubule- and Rab11-dependent apical transport during tissue invagination
Thao Phuong Le, SeYeon Chung
Abstract
During tissue invagination, contractile actomyosin structures generate the cellular forces that drive apical constriction. Using the Drosophila embryonic salivary gland as a model for epithelial tube formation, we show that microtubule- and Rab11-dependent apical transport is critical for regulating actomyosin networks during invagination.
Topics & Concepts
BiologyApical constrictionMicrotubuleCell biologyConstrictionInvaginationEpithelial tissueApical membraneTransport proteinAnatomyBiophysicsMorphogenesisBiochemistryEpitheliumGeneticsEndocrinologyGeneMicrotubule and mitosis dynamicsCellular transport and secretionCellular Mechanics and Interactions