Nanoscopic insights into the surface conformation of neurotoxic amyloid β oligomers
Martina Banchelli, Roberta Cascella, Cristiano D’Andrea, Leszek Cabaj, Iacopo Osticioli, Daniele Ciofini, Mai Suan Li, Krzysztof Skupień, Marella de Angelis, Salvatore Siano, Cristina Cecchi, Roberto Pini, Giovanni La Penna, Fabrizio Chiti, Paolo Matteini
Abstract
Unraveling characteristic structural determinants at the basis of Aβ<sub>42</sub> oligomers' neurotoxicity by a sub-molecular SERS investigation of their surface.
Topics & Concepts
Nanoscopic scaleAmyloid βAtomic force microscopyAmyloid fibrilNanotechnologyAmyloid (mycology)Surface (topology)Materials scienceChemistryGeometryMedicineMathematicsInorganic chemistryDiseasePathologyAlzheimer's disease research and treatmentsComputational Drug Discovery MethodsLipid Membrane Structure and Behavior