Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
Lingtian Zhang, Naga Rajiv Lakkaniga, Jaideep B. Bharate, Nicholas McConnell, Xiuqi Wang, Anupreet Kharbanda, Yuet‐Kin Leung, Brendan Frett, Neil P. Shah, Hongyu Li
Topics & Concepts
Myeloid leukemiaChemistryFms-Like Tyrosine Kinase 3ThiopheneKinaseCD135Cancer researchLeukemiaIndazoleTyrosine-kinase inhibitorTyrosine kinasePharmacologyMutationSignal transductionReceptor tyrosine kinaseBiochemistryStereochemistryBiologyCancerImmunologyGeneticsGeneOrganic chemistryAcute Myeloid Leukemia ResearchProtein Degradation and InhibitorsChronic Myeloid Leukemia Treatments