Disulfide based prodrugs for cancer therapy
Qiang Wang, Jiankun Guan, Jiangling Wan, Zifu Li
Abstract
settings. Based on these insights, we analyze the impact of electronics, steric hindrance and substituent position of the disulfide linker on the extracellular stability and intracellular cleavage rate of disulfide containing prodrugs. Current challenges and future opportunities for the disulfide linker are provided at the end.
Topics & Concepts
ProdrugCancer therapyDisulfide bondChemistryCombinatorial chemistryCancerPharmacologyMedicineInternal medicineBiochemistryRNA Interference and Gene DeliverySynthesis and Characterization of Heterocyclic CompoundsAdvanced biosensing and bioanalysis techniques