Hydrogen bonding-enabled gold catalysis: ligand effects in gold-catalyzed cycloisomerizations in hexafluoroisopropanol (HFIP)
Nikolaos V. Tzouras, Alberto Gobbo, Nestor Bracho Pozsoni, Savvas G. Chalkidis, Subhrajyoti Bhandary, Kristof Van Hecke, Georgios C. Vougioukalakis, Steven P. Nolan
Abstract
Gold catalysis has witnessed immense evolution in recent years, yet it still requires the use of activators to render the common [AuCl(L)] complexes catalytically active. Herein, the H-bonding donor properties of hexafluoroisopropanol (HFIP) are utilized for Au-Cl bond activation and the ancillary ligand and counteranion effects on cycloisomerization reactions are showcased in HFIP as solvent.
Topics & Concepts
CycloisomerizationCatalysisLigand (biochemistry)ChemistrySolventHydrogen bondCombinatorial chemistryPhotochemistryOrganic chemistryMoleculeReceptorBiochemistryCatalytic Alkyne ReactionsCatalysis for Biomass ConversionAsymmetric Hydrogenation and Catalysis