A decellularized spinal cord extracellular matrix-gel/GelMA hydrogel three-dimensional composite scaffold promotes recovery from spinal cord injury <i>via</i> synergism with human menstrual blood-derived stem cells
Wenhua He, Xuanxuan Zhang, Xiangzhe Li, Dingyue Ju, Tiantian Mao, Yan Lü, Yu Gu, Longju Qi, Qinghua Wang, Qinfeng Wu, Chuanming Dong
Abstract
results showed that the combined use of the DSCG/GelMA composite scaffold with MenSCs improved the motor function, reduced the inflammatory response, promoted neuronal differentiation, and inhibited the proliferation of reactive astrocytes after spinal cord injury. Altogether, our study provided a promising novel therapeutic option of using bioactive materials synergistic with stem cells for the treatment of SCI.
Topics & Concepts
DecellularizationSpinal cordExtracellular matrixComposite numberSpinal cord injuryMaterials scienceScaffoldBiomedical engineeringMatrix (chemical analysis)Regeneration (biology)ChemistryMedicineComposite materialCell biologyBiologyPsychiatryBiochemistryElectrospun Nanofibers in Biomedical ApplicationsNerve injury and regenerationTissue Engineering and Regenerative Medicine