NMR Metabolomics Assessment of Osteogenic Differentiation of Adipose-Tissue-Derived Mesenchymal Stem Cells
Daniela S. C. Bispo, Catarina S. H. Jesus, Marlene Correia, Filipa Ferreira, Giulia Bonifazio, Brian J. Goodfellow, Mariana B. Oliveira, João F. Mano, Ana M. Gil
Abstract
); and metabolic players in protective antioxidative mechanisms (such as glutathione and specific amino acids). Different metabolic stages are proposed and are supported by putative biochemical explanations for the metabolite changes observed. This work lays the groundwork for the use of untargeted NMR metabolomics to find potential metabolic markers of osteogenic differentiation efficacy.
Topics & Concepts
Mesenchymal stem cellMetabolomicsCitric acid cycleGlycolysisBiochemistryAdipose tissueMetabolic pathwayMetabolomeMetabolismBiologyCell biologyOxidative phosphorylationChemistryBioinformaticsMetabolomics and Mass Spectrometry StudiesCancer, Hypoxia, and MetabolismAdipose Tissue and Metabolism