Design and synthesis of improved active-site SHP2 inhibitors with anti-breast cancer cell effects
Dhanaji M. Lade, Roxy Nicoletti, James Mersch, Yehenew M. Agazie
Topics & Concepts
ChemistryActive siteAllosteric regulationProtein tyrosine phosphataseEnzymeBinding siteProto-oncogene tyrosine-protein kinase SrcKinaseIn silicoDocking (animal)Receptor tyrosine kinaseStereochemistrySubstrate (aquarium)Lead compoundBiochemistrySelectivityIn vitroBiologyMedicineNursingCatalysisEcologyGeneProtein Tyrosine PhosphatasesPI3K/AKT/mTOR signaling in cancerBioactive Compounds and Antitumor Agents