Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes
Amélie I. S. Sobczak, Kondwani Katundu, Fladia Phoenix, Siavash Khazaipoul, Ruitao Yu, Fanuel Lampiao, Fiona Stefanowicz, Claudia A. Blindauer, Samantha J. Pitt, Terry Smith, Ramzi Ajjan, Alan J. Stewart
Abstract
-vaccenate) NEFAs positively correlating with clot density. Collectively, these data strongly support the concept that elevated NEFA levels contribute to altered coagulation in T2DM through dysregulation of plasma zinc speciation.
Topics & Concepts
AlbuminZincType 2 diabetesBlood clottingChemistryClotting factorBiochemistryDiabetes mellitusBiologyInternal medicineMedicineEndocrinologyOrganic chemistryTrace Elements in HealthDrug Transport and Resistance MechanismsHemoglobinopathies and Related Disorders