Carbon isotope labeling of carbamates by late-stage [<sup>11</sup>C], [<sup>13</sup>C] and [<sup>14</sup>C]carbon dioxide incorporation
Antonio Del Vecchio, Alex Talbot, Fabien Caillé, Arnaud Chevalier, Antoine Sallustrau, Olivier Loreau, Gianluca Destro, Frédéric Taran, Davide Audisio
Abstract
A general procedure for the late-stage [11C], [13C] and [14C]carbon isotope labeling of cyclic carbamates is reported. This protocol allows the incorporation of carbon dioxide, the primary source of carbon-14 and carbon-11 radioisotopes, in a direct, cost-effective and sustainable manner. A disconnection/reconnection strategy, involving ring opening/isotopic closure, was also implemented.
Topics & Concepts
Carbon-13ChemistryRadiochemistryCarbon-14IsotopeCarbon dioxideCarbon fibersIsotopes of carbonPhysicsNuclear physicsMaterials scienceOrganic chemistryComposite numberComposite materialChemical Reactions and IsotopesAmino Acid Enzymes and MetabolismMedical Imaging Techniques and Applications