CRISPR Screens Identify <i>Toxoplasma</i> Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells
Shruthi Krishnamurthy, Parag Maru, Yifan Wang, Mebratu A. Bitew, Debanjan Mukhopadhyay, Yoshiki Yamaryo‐Botté, Tatiana C. Paredes-Santos, Lamba Omar Sangaré, Christopher Swale, Cyrille Y. Botté, Jeroen P. J. Saeij
Abstract
Toxoplasma infection causes serious complications in immunocompromised individuals and in the developing fetus. During infection, certain immune cells release a protein called interferon gamma that activates cells to destroy the parasite or inhibit its growth.
Topics & Concepts
Parasite hostingGeneInterferonImmune systemBiologyInterferon gammaVirologyCRISPRToxoplasma gondiiMicrobiologyImmunologyAntibodyGeneticsComputer scienceWorld Wide WebToxoplasma gondii Research StudiesCytomegalovirus and herpesvirus researchinterferon and immune responses