A presynaptic phosphosignaling hub for lasting homeostatic plasticity
Johannes Alexander Müller, Julia Betzin, Jorge Santos-Tejedor, Annika Mayer, Ana‐Maria Oprişoreanu, Kasper Engholm‐Keller, Isabelle Paulußen, Polina Gulakova, Terrence Daniel McGovern, Lena Johanna Gschossman, Eva Schönhense, Jesse R. Wark, Alf Lamprecht, Albert J. Becker, Ashley J. Waardenberg, Mark E. Graham, Dirk Dietrich, Susanne Schoch
Abstract
. Our data suggest that SRPK2 and RIM1 represent a presynaptic phosphosignaling hub that is involved in the homeostatic balance of synaptic coupling of neuronal networks.
Topics & Concepts
Homeostatic plasticitySynaptic plasticityHomeostasisNeuroscienceGlutamate receptorSynaptic scalingBiologyPhosphorylationSynaptic vesicleScaffold proteinMetaplasticityCell biologyVesicleSignal transductionBiochemistryReceptorMembraneNeuroscience and Neuropharmacology ResearchCellular transport and secretionLipid Membrane Structure and Behavior