Effect of ECOG performance status on outcomes in patients with acute myeloid leukemia and other high-grade myeloid neoplasms
Gabrielle Paras, Megan Othus, Kelda Schonhoff, Carole Shaw, Mohamed L. Sorror, Anna B. Halpern, Jacob Appelbaum, Paul C. Hendrie, Roland B. Walter, Elihu H. Estey, Mary‐Elizabeth M. Percival
Abstract
For acute myeloid leukemia (AML), survival remains poor among older patients due to significant comorbidities and poorer performance status (PS) [ 1 ]. This finding likely reflects an association with genomic abnormalities predictive of resistance to current therapies and a propensity for death within 28 days of treatment (treatment-related mortality or TRM) [ 2 , 3 ]. Poor PS is an important determinant of TRM. The widely-used Eastern Cooperative Oncology Group (ECOG) system assigns bed-ridden patients PS 4, patients in bed >50% of the usual waking hours PS 3, and patients who are able to perform the great majority of their usual activities PS 0 or 1, with the latter somewhat more impaired than the former [ 4 ].