An Organocopper(III) Fluoride Triggering C−CF<sub>3</sub> Bond Formation
Daniel Joven‐Sancho, Andrea Echeverri, Nathalie Saffon‐Merceron, Julia Contreras‐García, Noel Nebra
Abstract
Abstract Copper(III) fluorides are catalytically competent, yet elusive, intermediates in cross‐coupling. The synthesis of [PPh 4 ][Cu III (CF 3 ) 3 F] ( 2 ), the first stable (isolable) Cu III −F, was accomplished via chloride addition to [Cu III (CF 3 ) 3 (py)] ( 1 ) yielding [PPh 4 ][Cu III (CF 3 ) 3 Cl(py)] ( 1 ⋅Cl), followed by treatment with AgF. The Cu III halides 1 ⋅Cl and 2 were fully characterized using nuclear magnetic resonance (NMR) spectroscopy, single crystal X‐ray diffraction (Sc‐XRD) and elemental analysis (EA). Complex 2 proved capable of forging C−CF 3 bonds from silyl‐capped alkynes. In‐depth mechanistic studies combining probes, theoretical calculations, trapping of intermediate 4 a ([PPh 4 ][Cu III (CF 3 ) 3 (C≡CPh)]) and radical tests unveil the key role of the Cu III acetylides that undergo facile 2 e − reductive elimination furnishing the trifluoromethylated alkynes (RC≡CCF 3 ), which are industrially relevant synthons in drug discovery, pharma and agrochemistry.