A Perspective on Organoids for Virology Research
Adithya Sridhar, Salvatore Simmini, Carla M. S. Ribeiro, Caroline Tapparel, Melvin M. Evers, Dasja Pajkrt, Katja C. Wolthers
Abstract
Animal models and cell lines are invaluable for virology research and host-pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to study viral infections in the human context. This perspective explores the potential of these organotypic cultures, also known as organoids, for virology research, antiviral testing, and shaping the virology landscape.
Topics & Concepts
Context (archaeology)VirologyPerspective (graphical)OrganoidBiologyComputational biologyCell biologyComputer scienceArtificial intelligencePaleontologyViral gastroenteritis research and epidemiologyVirus-based gene therapy researchRespiratory viral infections research