Litcius/Paper detail

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Hugo Sepúlveda, Xiang Li, Leo J. Arteaga-Vazquez, Isaac F. López-Moyado, Melina Brunelli, Lot Hernández-Espinosa, Xiaojing Yue, J. Carlos Angel, Caitlin W. Brown, Zhen Dong, Natasha Jansz, Fabio Puddu, Aurélie Modat, Jamie Scotcher, Páidí Creed, Patrick H. Kennedy, Cindy Manriquez-Rodriguez, Samuel A. Myers, R. M. M. Crawford, Geoffrey J. Faulkner, Anjana Rao

2025Nature Structural & Molecular Biology11 citationsDOIOpen Access PDF

Topics & Concepts

Transposable elementHeterochromatinDNA demethylationGenomeDNADemethylationGeneticsBiologyHeterochromatin protein 1Cell biologyDNA Transposable ElementsDNA methylationChemistryGene expressionGeneChromatinChromosomal and Genetic VariationsEpigenetics and DNA MethylationRNA modifications and cancer