Lovastatin/SN38 co-loaded liposomes amplified ICB therapeutic effect via remodeling the immunologically-cold colon tumor and synergized stimulation of cGAS-STING pathway
Yi Yang, Jialong Qi, Jialin Hu, You Zhou, Jiena Zheng, Wenxia Deng, Wenxia Deng, Muhammad Inam, Jiaxin Guo, Yongyi Xie, Yuan Li, Chuanshan Xu, Wei Deng, Wei Deng, Wenjie Chen
Topics & Concepts
StingLovastatinCancer researchImmune systemImmunotherapyColorectal cancerMedicineCancer immunotherapyImmune checkpointPharmacologyDNA damageMevalonate pathwayCancerBiologyImmunologyInternal medicineDNABiochemistryAerospace engineeringEnzymeReductaseEngineeringCholesterolinterferon and immune responsesCancer Mechanisms and TherapyRNA modifications and cancer