Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway
Zhihui Chen, Jing Yu, Menglu Fu, Ruolan Dong, Yan Yang, Jinlan Luo, Shuiqing Hu, Wenhua Li, Xizhen Xu, Ling Tu
Topics & Concepts
AMPKSirtuin 1SenescenceAMP-activated protein kinaseOxidative stressDipeptidyl peptidase-4Umbilical veinEndothelial stem cellEndotheliumCell biologyEndothelial dysfunctionChemistryProtein kinase AEndocrinologyPharmacologyBiologyInternal medicineDownregulation and upregulationMedicineKinaseIn vitroBiochemistryDiabetes mellitusType 2 diabetesGeneRetinal Diseases and TreatmentsSirtuins and Resveratrol in MedicineNitric Oxide and Endothelin Effects