WTAP Targets the METTL3 m <sup>6</sup> A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection
Matthew T. Sacco, Katherine M. Bland, Stacy M. Horner
Abstract
Positive-strand RNA viruses such as HCV represent a significant global health burden. Previous work has described that HCV RNA contains the RNA modification m 6 A and how this modification regulates viral infection.
Topics & Concepts
BiologyVirologyRNACytoplasmMethyltransferaseCell biologyGeneticsDNAGeneMethylationRNA modifications and cancerCancer-related molecular mechanisms researchHepatitis C virus research