Antibodies to nodal/paranodal proteins in paediatric immune-mediated neuropathy
Désirée De Simoni, Gerda Ricken, Michael Winklehner, Inga Koneczny, Michael Karenfort, Ulf Hustedt, Ulrich Seidel, Omar Abdel‐Mannan, Pinki Munot, Simon Rinaldi, Claudia Steen, Michael Freilinger, Markus Breu, Rainer Seidl, Markus Reindl, Julia Wanschitz, Cinta Lleixà, Günther Bernert, Klaus‐Peter Wandinger, Ralf Junker, Luís Querol, Frank Leypoldt, Kevin Rostásy, Romana Höftberger
Abstract
Patients with nodal/paranodal antibodies represent a specific subgroup of inflammatory peripheral neuropathies, whose clinical presentation with a prolonged subacute phase, additional symptoms such as ataxia and tremor, and poor treatment response to IV immunoglobulin (IVIG) often differs from classic Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP).1 The authors thank Valerie Pichler and Sopie Dürauer for technical assistance and Andreas Spittler from the Flow Cytometry Core facility of the MUV for technical support.