Copper(II)‐Catalysed Aerobic Oxidative Coupling of Arylamines with Hexafluoroisopropanol: An Alternative Methodology for Constructing Fluorinated Compounds
Liangying Wu, Yang Song, Zhanchong Li, Jiabao Guo, Xiaoquan Yao
Abstract
Abstract The selective functionalisation of arylamine derivatives with hexafluoroisopropanol through copper(II)‐catalysed aerobic oxidative coupling was developed to generate various fluoroalkylated arylamines under mild conditions. This method has a wide substrate scope with excellent functional group tolerance and provides the fluorinated products in good to excellent yields. Furthermore, preliminary studies indicate that this reaction occur via a radical mechanism. This protocol, which uses atmospheric O 2 as an oxidant, provides an alternative green route for constructing fluorinated compounds. magnified image
Topics & Concepts
ChemistryFunctional groupSubstrate (aquarium)Oxidative coupling of methaneOxidative phosphorylationCopperScope (computer science)Combinatorial chemistryReaction conditionsCoupling (piping)RadicalOrganic chemistryCatalysisBiochemistryEngineeringMechanical engineeringPolymerProgramming languageComputer scienceOceanographyGeologyFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods