Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease
Brandon J. Payliss, Ying Wah Elizabeth Tse, Sean E. Reichheld, Alexander Lemak, Hwa Young Yun, Scott Houliston, Ayushi Patel, C.H. Arrowsmith, Simon Sharpe, Haley D.M. Wyatt
Abstract
and identify the MUS81-binding interface. Our work provides mechanistic insights into how cell cycle-regulated phosphorylation of SLX4 drives the recruitment and activation of MUS81-EME1.
Topics & Concepts
Cell biologyBiologyPhosphorylationEndonucleaseHolliday junctionNucleasePLK1Cyclin-dependent kinase 1Cell cycleDNA repairDNAGeneticsCellDNA Repair MechanismsGenomics and Chromatin DynamicsCRISPR and Genetic Engineering