Human innate lymphoid cell precursors express CD48 that modulates ILC differentiation through 2B4 signaling
Dejene M. Tufa, Ashley Yingst, G. Devon Trahan, Tyler Shank, Dallas Jones, Seonhui Shim, Jessica Lake, Kevin Winkler, Laura M. Cobb, Renee Woods, Kenneth L. Jones, Michael R. Verneris
Abstract
precursors give rise to tissue-associated ILCs in vivo. We also observed that the interaction of 2B4 with CD48 induced differentiation of ILC2s, and together, these findings show that expression of CD48 by human ILCPs modulates ILC differentiation.
Topics & Concepts
Innate lymphoid cellProgenitor cellCell biologyInnate immune systemBiologyProgenitorLymphopoiesisCellCellular differentiationSignal transductionImmunologyStem cellGeneGeneticsImmune systemIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionEosinophilic Esophagitis