Inhibition of Na<sub>V</sub>1.7: the possibility of ideal analgesics
Yutaka Kitano, Tsuyoshi Shinozuka
Abstract
models and clinical results, the potential reasons behind the disconnect between preclinical results and clinical outcomes are discussed together with strategies for developing ideal analgesic agents.
Topics & Concepts
In vivoPharmacologyAnalgesicMedicineSodium channelAnalgesic agentsAdverse effectDrugChemistrySodiumBiologyOrganic chemistryBiotechnologyIon channel regulation and functionCardiac electrophysiology and arrhythmiasIon Transport and Channel Regulation