Millet shell polyphenols prevent atherosclerosis by protecting the gut barrier and remodeling the gut microbiota in ApoE<sup>−/−</sup> mice
Fengming Liu, Shuhua Shan, Hanqing Li, Jiangying Shi, Ruilin Hao, Ruipeng Yang, Zhuoyu Li
Abstract
mice with a high-fat diet, which is characterized by the enriched Oscillospira and Ruminococcus, and the abridged Allobaculum at the genus level. Collectively, these results suggest that MSPs regulate the integrity of the gut barrier and the structure of the gut microbiota, ultimately inhibiting the development of atherosclerotic plaques. This study provides new insights into the potential cardiovascular protective effects induced by millet shell polyphenols.
Topics & Concepts
OccludinGut floraTight junctionLipopolysaccharideBiologyTumor necrosis factor alphaInflammationApolipoprotein EBiochemistryChemistryMicrobiologyImmunologyInternal medicineMedicineDiseaseBarrier Structure and Function StudiesGut microbiota and healthHelicobacter pylori-related gastroenterology studies