Antiviral Properties of the LSD1 Inhibitor SP-2509
Mitchell R. Harancher, Jessica E. Packard, Shane P. Cowan, Neal A. DeLuca, Jill A. Dembowski
Abstract
Treatment of HSV-1-infected cells with SP-2509 blocked viral DNA replication, gene expression after the onset of DNA replication, and virus production. These data support a potential new role for LSD1 in the regulation of viral DNA replication and successive steps in the virus life cycle, and further highlight the promising potential to utilize LSD1 inhibition as an antiviral approach.
Topics & Concepts
BiologyViral replicationVirologyVirusReplication (statistics)DNA replicationDNAViral entryGeneViral life cycleGeneticsHerpesvirus Infections and TreatmentsViral Infections and Immunology ResearchPlant Virus Research Studies