Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel
Xin Jin, Hu‐Ri Piao, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen
Topics & Concepts
ChemistryEtravirineNevirapineStereochemistryReverse transcriptaseSelectivityDocking (animal)Structure–activity relationshipMolecular modelSide chainEC50Nucleoside Reverse Transcriptase InhibitorReverse-transcriptase inhibitorLead compoundPyrimidineHuman immunodeficiency virus (HIV)In vitroBiochemistryRNAOrganic chemistryGeneViral loadNursingPolymerMedicineCatalysisAntiretroviral therapyFamily medicineHIV/AIDS drug development and treatmentSynthesis and Characterization of Heterocyclic CompoundsPneumocystis jirovecii pneumonia detection and treatment