Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy
Lina Gao, Lei Zhang, Xuyu Zhu, Jing Chen, Zhao Meng, Simin Li, Chengli Yu, Lihong Hu, Hongzhi Qiao, Zijian Guo
Abstract
We herein report a hybrid nanocomposite (AuNRs-CTN@THA) which is based on hyaluronic acid-coated gold nanorods with loading of a copper complex through strong bonds. AuNRs-CTN@THA exhibits durable photothermal conversion capacity for pH-dominant and pH/temperature dual sensitive drug release, accomplishing synergetic antitumor efficacy and deep tumor penetration.
Topics & Concepts
NanorodHyaluronic acidPhotothermal therapyCopperMaterials scienceNanotechnologyCancer therapyCancerMetallurgyMedicineInternal medicineAnatomyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryAdvanced Nanomaterials in Catalysis