Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin
Melinda Hersey, Srimal Samaranayake, Shane N. Berger, Navid Tavakoli, Sergio Mena, H. Frederik Nijhout, Michael C. Reed, Janet Best, Randy Blakely, Lawrence P. Reagan, Parastoo Hashemi
Abstract
Acute LPS-induced inflammation (1) increases CNS histamine, (2) decreases CNS serotonin (via inhibitory histamine receptors), and (3) prevents a selective serotonin reuptake inhibitor (SSRI) from effectively increasing extracellular serotonin. A targeted depletion of histamine recovers SSRI-induced increases in extracellular hippocampal serotonin.
Topics & Concepts
SerotoninEscitalopramHistamineSerotonin Uptake InhibitorsSerotonin Plasma Membrane Transport ProteinsInflammationPharmacologyAntidepressantInternal medicineEndocrinologySerotonin transporterMedicineHippocampusReceptorFluoxetineTryptophan and brain disordersNeuroendocrine regulation and behaviorNeuroinflammation and Neurodegeneration Mechanisms