Exosomes derived from oral squamous cell carcinoma tissue accelerate diabetic wound healing
Maojie Zhang, Jiahe Guo, Kaituo Xiang, Jing Chen, Cheng Wang, Tao Jiang, Yu Kang, Xiang Xu, Jin Li, Xiaofan Yang, Zhenbing Chen
Abstract
Diabetic wound healing has become a public health issue that lacks effective treatment. We collected oral squamous cell carcinoma samples and paracancerous tissue and extracted Ti-Exos for verification. In vitro assays revealed that OSCC Ti-EVs could enhance the proliferation and migration of endothelial cells, keratinocytes, and fibroblasts in diabetic cell model. In vivo assays also verified that OSCC Ti-Exos could promote diabetic wound healing, demonstrated preliminary biosafety in mice, and have promise as therapeutic applications.
Topics & Concepts
MicrovesiclesWound healingExosomeCancer researchIn vivoCellMedicineCell migrationIn vitroImmunologyChemistryBiologymicroRNABiotechnologyBiochemistryGeneExtracellular vesicles in diseaseWound Healing and TreatmentsElectrospun Nanofibers in Biomedical Applications