Resonant acoustic mixing enables solvent-less amide coupling in solid-phase peptide synthesis
Alice Nanni, Panayiotis Bilalis, Magnus Rueping
Abstract
Resonant acoustic mixing (RAM) as a mechanochemical alternative to traditional SPPS processes enables efficient and scalable peptide coupling without added solvent, supporting sustainable synthesis of bioactive peptides.
Topics & Concepts
Mixing (physics)Coupling (piping)PeptideAmideMaterials sciencePeptide synthesisCombinatorial chemistryChemistryScalabilityNanotechnologyChemical physicsChemical engineeringChemical synthesisCrystallography and molecular interactionsChemical Synthesis and AnalysisForce Microscopy Techniques and Applications