Convergent chemoenzymatic synthesis of <i>O</i>-GalNAc rare cores 5, 7, 8 and their sialylated forms
Madhusudhan Reddy Gadi, Congcong Chen, Shumin Bao, Shuaishuai Wang, Yuxi Guo, Jinghua Han, Weidong Xiao, Lei Li
Abstract
Mucin rare cores 5, 7, and 8 with 1,2-cis glycosidic bonds were prepared with exclusive stereo-selectivity from a versatile precursor. Enzyme-catalyzed regio-selective sialylation was then achieved, yielding natural sialylated rare cores.
Topics & Concepts
Glycosidic bondChemistrySelectivityMucinStereochemistryEnzymeCombinatorial chemistryBiochemistryCatalysisCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchMicrobial Natural Products and Biosynthesis