Microwell array chip-based single-cell analysis
Jin Zhang, Jing Xue, Ningfeng Luo, Feng Chen, Badong Chen, Yongxi Zhao
Abstract
analysis ability, making it an ideal technique for single-cell studies. Herein, recent advances of single-cell analysis based on microwell array chips are summarized. We first introduce the design and preparation of different microwell chips. Then microwell-based cell capture and lysis strategies are discussed. We finally focus on advanced microwell-based analysis of single-cell proteins, nucleic acids, and metabolites. The challenges and opportunities for the development of microwell-based single-cell analysis are also presented.
Topics & Concepts
MicrofluidicsSingle-cell analysisComputer scienceNanotechnologyProfiling (computer programming)Computational biologyCellChemistryBiologyMaterials scienceOperating systemBiochemistryInnovative Microfluidic and Catalytic Techniques InnovationMicrofluidic and Bio-sensing TechnologiesMicrofluidic and Capillary Electrophoresis Applications