Resistance-exercise training attenuates LPS-induced astrocyte remodeling and neuroinflammatory cytokine expression in female Wistar rats
Taylor J. Kelty, Xuansong Mao, Nathan R. Kerr, Thomas E. Childs, Gregory N. Ruegsegger, Frank W. Booth
Abstract
To further elucidate the known cognitive health benefits from resistance-exercise training, we tested if resistance-exercise training in rats would attenuate lipopolysaccharide-induced neuroinflammation. Our data demonstrated that resistance training had an anti-inflammatory effect in the brain as LPS-induced neuroinflammatory cytokine expression and reactive astrocytic remodeling were reduced in the dentate gyrus after 3 wk of progressive ladder climbing.
Topics & Concepts
NeuroinflammationDentate gyrusMedicineAstrocytePsychologyInflammationNeuroscienceInternal medicineEndocrinologyHippocampusCentral nervous systemNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersIntensive Care Unit Cognitive Disorders