Decursin inhibits cell growth and autophagic flux in gastric cancer via suppression of cathepsin C.
Solbi Kim, Sang Il Lee, Nayoung Kim, Mina Joo, Kyung-Ha Lee, Myung-Won Lee, Heung Jin Jeon, Hyewon Ryu, Jin‐Man Kim, Ji-Young Sul, Gyu‐Yong Song, Jiyeon Kim, Hyo Jin Lee
Abstract
. We established spheroid and patient-derived organoid models and found that decursin decreased the growth of spheroids and patient-derived gastric organoids, as well as modulated the expression of CTSC and autophagy-related proteins. Hence, our findings uncovered a previously unknown mechanism by which decursin regulates cell growth and autophagy and suggests that decursin may act as a potential therapeutic agent that simultaneously inhibits cell growth and autophagy.
Topics & Concepts
AutophagyCancerCancer researchCell growthCancer cellCathepsinCathepsin DCathepsin BCathepsin CCell cycleCellChemistryCell biologyBiologyApoptosisMedicineInternal medicineBiochemistryEnzymeAutophagy in Disease and TherapyGinseng Biological Effects and ApplicationsBioactive Natural Diterpenoids Research