Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin
Jesper Bäckdahl, Lovisa Franzén, Lucas Massier, Qian Li, Jutta Jalkanen, Hui Gao, Alma Andersson, Nayanika Bhalla, Anders Thorell, Mikael Rydén, Patrik L. Ståhl, Niklas Mejhert
Abstract
displayed a transcriptional response to insulin. Altogether, by mining this multimodal resource we identify that human WAT is composed of three classes of mature adipocytes, only one of which is insulin responsive.
Topics & Concepts
AdipocyteBiologyInsulinInsulin sensitivityComputational biologyAdipose tissueInsulin resistanceEndocrinologySingle-cell and spatial transcriptomicsAdipokines, Inflammation, and Metabolic DiseasesNutritional Studies and Diet