Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking
Horia Pribiag, Sora Shin, Eric Hou-Jen Wang, Fangmiao Sun, Paul Datta, Alexander S. Okamoto, Hayden Guss, Akanksha Jain, Xiaoyun Wang, Bruna De Freitas, Patrick Honma, Stefan Carl Pate, Varoth Lilascharoen, Yulong Li, Byung Kook Lim
Abstract
neuronal populations projecting to either the lateral habenula (LHb) or the ventral tegmental area (VTA) display different patterns of activity during drug seeking following abstinence from cocaine self-administration and that selective suppression of elevated activity or DRD3 signaling in the LHb-projecting population reduces drug seeking. Together, our results uncover how circuit-specific DRD3-mediated plasticity contributes to the process of drug relapse.
Topics & Concepts
DopamineNeuroscienceChemistryPsychologyNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms