Uncovering the Hidden Antibiotic Potential of Cannabis
Maya A. Farha, Omar M. El-Halfawy, Robert T. Gale, Craig R. MacNair, Lindsey A. Carfrae, Xiong Zhang, Nicholas G. Jentsch, Jakob Magolan, Eric D. Brown
Abstract
efficacy of cannabigerol in a murine systemic infection model caused by MRSA. We also show that cannabinoids are effective against Gram-negative organisms whose outer membrane is permeabilized, where cannabigerol acts on the inner membrane. Finally, we demonstrate that cannabinoids work in combination with polymyxin B against multidrug resistant Gram-negative pathogens, revealing the broad-spectrum therapeutic potential for cannabinoids.
Topics & Concepts
AntibioticsMicrobiologyPolymyxinAntibiotic resistanceStaphylococcus aureusBiologyAntimicrobialBacteriaDrug resistanceMultiple drug resistanceGeneticsCannabis and Cannabinoid ResearchClostridium difficile and Clostridium perfringens researchAntibiotic Resistance in Bacteria