Mesenchymal stem cell-derived exosomes: a possible therapeutic strategy for repairing heart injuries
Zeshu Zhu, Ping Zhu, Xiongwei Fan, Xiaoyang Mo, Xiushan Wu
Abstract
Mesenchymal stem cells (MSCs) are one of the most potent therapeutic strategies for repairing cardiac injury. It has been shown in the latest studies that MSCs cannot survive in the heart for a long time. Consequently, the exosomes secreted by MSCs may dominate the repair of heart injury and promote the restoration of cardiac cells, vascular proliferation, immune regulation, etc. Based on the current research, the progress of the acting mechanism, application prospects and challenges of exosomes, including non-coding RNA, in repairing cardiac injuries are summarised in this article.
Topics & Concepts
Mesenchymal stem cellMicrovesiclesExosomeMedicineImmune systemMechanism (biology)Stem cellCell biologymicroRNABioinformaticsImmunologyBiologyCancer researchGeneBiochemistryPhilosophyEpistemologyExtracellular vesicles in diseaseFuel Cells and Related MaterialsCircular RNAs in diseases